Danganronpa 3: The End of Hope's Peak High School

Chisa Yukizome, a former student at Hope's Peak Academy gets hired as a new teacher for Class 1 - B. However, most of the students didn't show up for class, leaving Chisa, Fuyuhiko Kuzuryu, Hiyoko Saionji, Mahiru Koizumi, Sonia Nevermind and Mikan Tsumiki to look for them. But things can get pretty crazy when the Ultimates are at play.

Chisa Yukizome takes her investigation to the Reserve Course and hopes to get information out of Hajime Hinata. Chiaki Nanami attempts to make friends by using her love of gaming to help her classmates bond, successfully bringing her crazy class together.

Natsumi pompous attitude gets her in an argument with Sato, the friend of photographer Mahiru Koizumi, who were both in a photography club with her. Trying to pry the two apart, Hajime learns of Natsumi's determination to get into the main course and be recognised by her brother. The next day, Hajime arrives at school to discover that Natsumi has been murdered, suspecting that Sato may have been responsible. After Sato is found dead a few days later, Hajime tries to confront Mahiru over what happened, but is stopped by security guard Juzo Sakakura, who insults his lack of talent. As Chisa and Juzo worry about the direction Hope's Peak Academy is heading, Hajime prepares to take part in an experiment held by the school to receive an artificial talent.

With the class preparing for a practical exam despite the gloominess following Sato's death, lucky student Nagito Komaeda approaches Seiko for a laxative he can use to postpone the exam. At the same time, Ruruka asks Seiko for a performance enhancing drug to use in her pastries for the exam. However, Nagito gets the two drugs mixed up, later accidentally getting his bag switched with Seiko's. As a result, Ruruka ends up using laxative in her sweets while Seiko finds herself with a switch to a bomb Nagito was planning to set off, leading the two to distrust each other. Elsewhere, the drug Nagito picked ends up causing a dog to grow in size and break into the gymnasium, causing the bomb to be accidentally set off. Following the chaos, Seiko, Ruruka, and Sonosuke are all expelled, Nagito is suspended, and Chisa is reassigned to the Reserve Class.

After spending half a year teaching the reserve class, Chisa asks Juzo for a trustee's ID in order to investigate something known as the Kamakura Project. Managing to return to her position as homeroom teacher of the 77th class, she is relieved to find that Chiaki has managed to keep everyone together and is given a warm welcome. Meanwhile, it is revealed that Ryota has been spending all of his time at home working on an anime, having the Ultimate Imposter take his place in class. Elsewhere, Junko Enoshima meets up with her sister, Mukuro Ikusaba, as they prepare to enroll into Hope's Peak as part of the 78th class. When Ryota ends up collapsing with a fever, the Ultimate Imposter seeks out nurse Mikan Tsumiki to treat him, explaining how he took on Ryota's identity so that he could stay at home and animate. As the new school year begins and the 78th class begin their life at Hope's Peak, Hajime goes through with the Kamakura Project.

With his original personality removed and his body infused with every known talent, Hajime emerges from the experiment under the new persona of Izuru Kamukura. Later, after the 77th class move into a new building, Chisa sneaks into the trustee's office, where she learns all about the Kamukura Project, which is designed to create a Super High School Level Hope. Meanwhile, Junko and Mukuro kidnap one of the trustees, using his eyeball to sneak into where Izuru is being held and try to sway him over to the side of despair. After getting knocked out by Izuru and winding up in hospital, Junko becomes excited when she encounters Ryota on his way to a check-up.