Sayonara Zetsubou Sensei

Kafuka Fuura is cheerily walking to school one April morning when she suddenly spots a man trying to hang himself in a fit of despair. Kafuka manages to use her weight to snap the rope, thus saving his life. Nozomu Itoshiki, the man, eventually cannot take anymore of the girl's ridiculous ramblings, and runs off to school to start homeroom at the beginning of a new school year. When Nozomu walks in the door, he finds Kafuka is one of his students.

After confiding in his latest despairs to Ms. Arai, she asks Nozomu to visit one of his students who hasn't shown up to school — Kiri Komori, a hikikomori. In the end Kiri goes to school but decides to be a hikimori there. The next day, Nozomu notes that another of his students, Matoi Tsunetsuki, didn't show up that day. Ms. Arai brings Nozomu to the counseling room, where she explains Matoi's obsessive-stalker tendencies to Nozomu. That night, he attempts to dissuade her from bothering her last boyfriend; however, his strategy backfires on him. This turns him into Matoi's latest object of affection.

This episode is a pastiche of parodies about foreigners and Japanese attitudes concerning them. A foreign student named Kaere Kimura transfers into the class. Kimura is a blonde girl with multiple personality disorder stemming from cultural identity confusion. Nozumu prevents her from committing suicide but sees her underwear and is sued. While Nozomu is absent from school Chiri investigates his students and discovers that Maria is an illegal immigrant.

Chie dispatches Nozomu to investigate rumors that the invariably injured Abiru Kobushi is suffering from domestic violence. He pursues Abiru's father while he shops, causing him a great deal of inconvenience, before discovering Abiru's obsession with pulling the tails of dangerous animals. The latter half of the episode concerns Meru Otonashi, who is silent and shy in person, but remarkably abusive via text-messaging, her only means of communication.

On physical examination day, many of the girls are feeling stress about their weight, measurements and fitness. Nozumu distracts them by deciding to judge the "social worth" of students so that they will know whether they are living "above their station." Kitsu seizes on this idea, scolding everyone who possesses any luxuries, appalling Nozumu to the point where he decides to go on a hedonistic binge before killing himself. In the second half he encounters some of his students at a hot spring and is frightened to learn the spring has the power to remove their "toxicity" giving them well-adjusted personalities.

Kafuka comes down with a cold during the summer and has to go see the doctor, Mikoto Itoshiki, who happens to be Nozomu's brother. Later, Chiri and Kafuka find out from Mikoto that Nozomu has gone back to his hometown in Kuraizawa for an arranged marriage. One way or another, the girls somehow all end up arriving at Kuraizawa, where they are taken to the Itoshiki residence by Tokita. Here they find out that the Itoshiki tradition for arranged marriages simply involves both parties exchanging eye contact. The rest of the episode involves Nozomu and his attempts to avoid eye contact with the girls and various other people/objects.