Dr. Ramune: Mysterious Disease Specialist

People become afflicted by "mysterious diseases" when their hearts and minds are affected by "the mysterious." Koto, a girl who produces mayonnaise from her eyes, visits Dr. Ramune, who specializes in these diseases that can't be explained by modern medicine. She was brought to the clinic by Ramune's apprentice Kuro. Koto explains that she also cries condiments other than mayonnaise, and Ramune offers her a mysterious treatment.

Ramune is visited by Kengo, a young man whose penis has turned into a chikuwa fish cake. Though there must be some reason for it, Kengo refuses to talk. When Kengo begs Ramune to fix it, even if it's only temporary, Ramune hands him a certain mysterious item. Kengo accepts the item and begins talking to a woman named Yui about going on a date, but...

Ramune uses his Shoji Vision to invite Kuro to a mysterious item shop. Kuro discovers the mysterious item shop Akatsuki at his destination. At first glance, the store appears to be a candy shop, but mysterious items are sold in the back. Kuro meets shopkeeper Nico and his great-grandmother and former shopkeeper Ayame, a girl who remembers her past lives, and is watching her make mysterious items with great interest when a strange man appears.

Takaharu, a high school student whose fingertips have turned into chili peppers, comes to see Ramune. He seems to have some idea as to why he's haunted by the mysterious. The mysterious nail clippers Ramune lends to him can be removed from their bag once Takaharu stops hiding his true self. Initially Takaharu can't even untie the drawstring, but...

A boy named Rio comes to the shrine. His mother is afflicted by a mysterious disease that has turned her ears into pot stickers. His mother claims not to know what the cause is, but she is distraught because they are preventing her not only from hearing the voices of others, but Rio's voice as well. Ramune explains that there are voices she can hear and voices she can't, and that it's an emotional problem. He decides to wait and see how her condition changes.

Rio learns that his mother's ears have turned into pot stickers because his older brother Yuu was kidnapped, and Rio feels responsible for what happened. When Rio nearly falls off a cliff while searching for Yuu, Ramune throws himself in harm's way to protect him and ends up badly injured. In order to save Ramune, Rio uses the Pearl of Night Voices he received from Ramune to treat his mother, desperately calling out to his mother, who can't hear his voice.