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Sandra Bullock
Scarlet Overkill (voice)
Jon Hamm
Herb Overkill (voice)
Michael Keaton
Walter Nelson (voice)
Allison Janney
Madge Nelson (voice)
Steve Coogan
Professor Flux / Tower Guard (voice)
Jennifer Saunders
Reine Elizabeth II (voice)
Geoffrey Rush
Narrator (voice)
Steve Carell
Gru (voice)
Pierre Coffin
Kevin / Stuart / Bob / The Minions (voice)
Katy Mixon
Tina (voice)
Michael Beattie
VNC Announcer / Walter Jr. (voice)
Hiroyuki Sanada
Sumo (voice)